SERCA2a inactivation by nitration is identified as a potential mechanism contributing to calcium pump failure in dilated cardiomyopathy.
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No immediate clinical implications in dilated cardiomyopathy; leaves open SERCA2a nitration as a target pending human validation.
We conclude that SERCA2a inactivation by nitration may contribute to Ca pump failure and hence heart failure in DCM.
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Lokuta et al. (2005) studied this question.
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