What question did this study set out to answer?

To provide a comprehensive overview of extracellular vesicle biology, isolation methodologies, proteomic data, and translational clinical applications.

May 10, 2011Cellular and Molecular Life SciencesOpen Access

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

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To provide a comprehensive overview of extracellular vesicle biology, isolation methodologies, proteomic data, and translational clinical applications.
Reviewed literature spanning prokaryotic and eukaryotic extracellular vesicles, including exosomes, microvesicles, and apoptotic bodies.
Synthesized and compared results from published proteomic studies and meta-analyses to evaluate vesicle cargo, detection methods, and technical artifacts.
Identified membrane vesicles as evolutionary conserved mediators of intercellular communication and immune regulation in physiological and pathological states.
Highlighted major methodological challenges and potential artifacts in vesicle isolation, classification, clearance, and detection.
Demonstrated broad clinical utility of extracellular vesicles as biomarkers for disease diagnostics and novel platforms for targeted therapy.

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Implication

Comprehensive review uncovers key functions and proteomic profiles of extracellular vesicles, highlighting novel diagnostic and therapeutic opportunities in translational medicine.

Cite This Study

György et al. (2011) studied this question.

synapsesocial.com/papers/69d972648988aeabbe685620 https://doi.org/10.1007/s00018-011-0689-3

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Implication

Comprehensive review uncovers key functions and proteomic profiles of extracellular vesicles, highlighting novel diagnostic and therapeutic opportunities in translational medicine.

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

Key Points

Discussion

Implication

Cite This Study

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

Key Points

Discussion

Implication

Cite This Study

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