Neuropathy associated with lymphoma

Electrophysiological studies have been performed on 62 subjects with malignant lymphoma and the results compared with those of 35 control subjects matched for age. There was evidence of impairment of conduction consistent with a generalized peripheral neuropathy in 22 subjects (35%). Histological and electronmicroscopic studies were performed on sural nerve biopsy material from five subjects, and the pathological abnormalities of the myelinated fibres were those of axonal degeneration and segmental demyelination. The unmyelinated fibres were not affected.