Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia

Dharmesh Hirani; Cristina M. Alvira; Soula Danopoulos; Carlos Milla; Michele Donato; Lü Tian; Jasmine Mohr; Katharina Dinger; Christina Vohlen; Jaco Selle; Silke van Koningsbruggen‐Rietschel; Verena Barbarino; Christian P. Pallasch; Stefan Rose‐John; Margarete Odenthal; Gloria Pryhuber; Siavash Mansouri; Rajkumar Savai; Werner Seeger; Purvesh Khatri; Denise Al Alam; Jörg Dötsch; Miguel A. Alejandre Alcázar

doi:10.1183/13993003.02248-2020

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Abstract

We present a novel IL-6-mediated mechanism by which hyperoxia activates macrophages in immature lungs, impairs ATII homeostasis and disrupts elastic fibre formation, thereby inhibiting lung growth. The data provide evidence that IL-6 trans-signalling could offer an innovative pharmacological target to enable lung growth in severe neonatal chronic lung disease.

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Hirani et al. (2021) studied this question.

synapsesocial.com/papers/69d979062a25b240b7a3c6e0 https://doi.org/10.1183/13993003.02248-2020

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Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia

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Macrophage-derived IL-6 trans-signalling as a novel target in the pathogenesis of bronchopulmonary dysplasia

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