Why the study?
Does bivalirudin dose correlate with creatinine clearance during treatment of heparin-induced thrombocytopenia?
Does bivalirudin dose correlate with creatinine clearance during treatment of heparin-induced thrombocytopenia?
Bivalirudin dosing in patients with heparin-induced thrombocytopenia requires careful individual titration due to high variability and correlation with renal function.
Bivalirudin dosing in HIT may require Clcr-guided titration given high variability; leaves open optimal regimens for prospective validation.
Bivalirudin dosing requirements increased with increasing Clcr values. The high degree of variability suggests that dosing in individual patients will require careful titration to achieve adequate anticoagulation.
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Runyan et al. (2011) studied this question.
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