Why the study?
What is the appropriate dosing and safety profile of bivalirudin in critically ill patients with HIT and hepatic and/or renal dysfunction?
Population
18 critically ill patients >18 years admitted to the ICU with hepatic and/or renal dysfunction, treated with…
Design
Cohort
Follow-up
mean 15 +/- 17 days
Authors
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Supports feasibility of adjusted bivalirudin dosing in this population; hypothesis-generating and requires randomized validation.
What is the appropriate dosing and safety profile of bivalirudin in critically ill patients with HIT and hepatic and/or renal dysfunction?
Bivalirudin can be safely used in critically ill patients with HIT and hepatic/renal dysfunction at lower initial doses (0.03-0.14 mg/kg/hour depending on the specific organ dysfunction).
Kiser et al. (2006) studied this question.
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