Why the study?
Does renal dysfunction or dialysis affect the initial bivalirudin dosing requirements to achieve a therapeutic aPTT goal in patients with heparin-induced thrombocytopenia?
Population
135 patients treated with bivalirudin for heparin-induced thrombocytopenia at a tertiary care medical…
Comparison
Bivalirudin dosing adjusted to achieve an… vs Patients with normal renal function receiving…
Design
Cohort
Authors
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May support lower initial bivalirudin dosing in renal impairment for HIT; hypothesis-generating and requires prospective validation.
Does renal dysfunction or dialysis affect the initial bivalirudin dosing requirements to achieve a therapeutic aPTT goal in patients with heparin-induced thrombocytopenia?
Patients with renal dysfunction require reduced initial doses of bivalirudin to reach therapeutic aPTT goals for HIT, with slightly higher requirements for those on hemodialysis compared to severe non-dialysis renal impairment.
Tsu et al. (2011) studied this question.
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