Why the study?
How do different direct thrombin inhibitors (bivalirudin, lepirudin, argatroban) affect INR values across various PT reagents?
How do different direct thrombin inhibitors (bivalirudin, lepirudin, argatroban) affect INR values across various PT reagents?
Direct thrombin inhibitors variably prolong INR depending on the specific drug, concentration, and PT reagent used, with argatroban having the greatest effect.
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INR interpretation requires caution with direct thrombin inhibitors; leaves open standardized human monitoring strategies.
Gosselin et al. (2004) studied this question.
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