July 6, 2004Annals of Pharmacotherapy

Comparing Direct Thrombin Inhibitors Using aPTT, Ecarin Clotting Times, and Thrombin Inhibitor Management Testing

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Why the study?

How do different aPTT reagents, ECT, and TIM compare in monitoring direct thrombin inhibitor concentrations in plasma?

Structured PICO

How do different aPTT reagents, ECT, and TIM compare in monitoring direct thrombin inhibitor concentrations in plasma?

Population

Pooled normal plasma samples containing direct thrombin inhibitors (DTIs) at low (0.1-1.2 microg/mL) and high (1.5-8.0 microg/mL) concentrations

Intervention

14 methods for measuring activated partial thromboplastin time (aPTT), ecarin clotting time (ECT), and thrombin inhibitor management test (TIM)

Comparator

Comparison between different reagents and tests

Outcome

Clotting times and their correlation with DTI drug concentrationsurrogate

There is significant variability among aPTT reagents in monitoring direct thrombin inhibitors, making ECT and TIM acceptable and potentially more consistent alternatives.

Authors

RGRobert C. GosselinGhent University Hospital JKJeffrey H. KingUniversity of California Davis Medical Center KJKim JanatpourSutter Medical Center

Discussion

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Implication

aPTT reagent sensitivity varies widely for DTIs; leaves open whether ECT/TIM offer more consistent monitoring in patients.

Cite This Study

Gosselin et al. (2004) studied this question.

synapsesocial.com/papers/6a8570d5481670416b109fef https://doi.org/10.1345/aph.1d565

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Comparing Direct Thrombin Inhibitors Using aPTT, Ecarin Clotting Times, and Thrombin Inhibitor Management Testing

Structured PICO

Discussion

Implication

Cite This Study

Comparing Direct Thrombin Inhibitors Using aPTT, Ecarin Clotting Times, and Thrombin Inhibitor Management Testing

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider