Population
In vitro clotting assays using human and bovine plasma and factor Xa
Comparison
Direct thrombin inhibitors vs Comparison among the four direct thrombin…
Design
Preclinical
Authors
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Variable PT effects among DTIs at equipotent APTT doses warrant agent-specific caution; animal data leave open human monitoring implications.
The variable prothrombin time prolongation among direct thrombin inhibitors is driven by the high molar plasma concentrations required for clinical effect in those with lower thrombin affinity.
Greinacher et al. (2005) studied this question.
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