January 27, 2014Clinical Science
The central renin–angiotensin system and sympathetic nerve activity in chronic heart failure
Population
Patients with chronic heart failure (CHF)
Design
Review
Authors
Discussion
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Member takes
Implication
Central RAAS imbalance may drive sympatho-excitation in CHF; hypothesis-generating for exercise effects and should not yet change practice.
Structured PICO
P
Population
Patients with chronic heart failure (CHF)
I
Intervention
Exercise training
This review highlights the pathophysiological role of central RAAS imbalance in driving sympathetic overactivation in chronic heart failure and the potential of exercise training to restore autonomic balance.
Cite This Study
Zucker et al. (2014) studied this question.