July 27, 2011PLoS ONEOpen Access

ACE2-Mediated Reduction of Oxidative Stress in the Central Nervous System Is Associated with Improvement of Autonomic Function

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Population

Mouse neuroblastoma cell line and in vivo ACE2 knockout (ACE2) mice and non-transgenic littermates

Comparison

ACE2 gene therapy targeted to the… vs Non-transgenic littermates and untreated…

Design

Preclinical

Follow-up

10 days

Authors

HXHuijing XiaHeart Failure & Transplant SSSonia SudaLouisiana State University Health Sciences Center New Orleans SBSharell M. BindomJoe DiMaggio Children's Hospital

Discussion

Member takes

Implication

Supports PVN-targeted ACE2 therapy for cardiac dysautonomia; hypothesis-generating in mice and untested in humans.

Structured PICO

Population

Mouse neuroblastoma cell line (Neuro2A cells) and in vivo ACE2 knockout (ACE2(-/y)) mice and non-transgenic (NT) littermates (young 12 weeks, mature 48 weeks)

Intervention

ACE2 gene therapy (Ad-hACE2) targeted to the paraventricular nucleus (PVN) and Angiotensin-II (AngII) infusion for 10 days

Comparator

Non-transgenic littermates and untreated baseline conditions

Outcome

Reactive oxygen species (ROS) formation, NADPH oxidase activity, and autonomic function (cardiac sympathetic tone)surrogate

ACE2 gene therapy targeted to the brain reduces oxidative stress and improves autonomic function, suggesting a potential therapeutic target for hypertension-associated dysautonomia.

Cite This Study

Xia et al. (2011) studied this question.

synapsesocial.com/papers/6a8eaa4b3d91093f4f11e17d https://doi.org/10.1371/journal.pone.0022682

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ACE2-Mediated Reduction of Oxidative Stress in the Central Nervous System Is Associated with Improvement of Autonomic Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ACE2-Mediated Reduction of Oxidative Stress in the Central Nervous System Is Associated with Improvement of Autonomic Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider