What question did this study set out to answer?

To review the mechanisms by which the peroxisome proliferator-activated receptor (PPAR) family regulates and attenuates excessive inflammatory responses.

March 29, 2019Inflammation ResearchOpen Access

Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors

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Authors

JKJan KorbeckiUniversity of Zielona Góra RBRafał BobińskiUniversity of Bielsko-Biała MDMieczysław DutkaUniversity of Bielsko-Biała

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Implication

Narrative review reveals mechanisms of NF-κB suppression by peroxisome proliferator-activated receptors in inflammatory pathways, highlighting their self-regulatory anti-inflammatory role.

Key Points

To review the mechanisms by which the peroxisome proliferator-activated receptor (PPAR) family regulates and attenuates excessive inflammatory responses.
Examined activation profiles of PPAR isoforms (PPARα, PPARβ/δ, PPARγ) by endogenous fatty acid derivatives, cyclopentenone prostaglandins, NSAIDs, and polyunsaturated fatty acids.
Analyzed direct and indirect molecular pathways through which PPAR signaling downregulates NF-κB transcription factor activity.
PPAR activation directly inhibits the inflammatory master switch NF-κB via direct binding to its p65 subunit or through ubiquitination that triggers p65 proteolytic degradation.
PPARs indirectly blunt NF-κB function by driving the expression of antioxidant enzymes (catalase, superoxide dismutase, heme oxygenase-1) to reduce reactive oxygen species and upregulating inhibitory regulators including IκBα, SIRT1, and PTEN.

Cite This Study

Korbecki et al. (2019) studied this question.

synapsesocial.com/papers/69d99fc85e5bcb4e3b8372c2 https://doi.org/10.1007/s00011-019-01231-1

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Implication

Narrative review reveals mechanisms of NF-κB suppression by peroxisome proliferator-activated receptors in inflammatory pathways, highlighting their self-regulatory anti-inflammatory role.

Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors

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Implication

Key Points

Cite This Study

Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors

Discussion

Member takes

Implication

Key Points

Cite This Study

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