Why the study?
Does levosimendan improve contractility, energy efficiency and mitochondrial respiration in a porcine model of acute ischaemic heart failure?
Does levosimendan improve contractility, energy efficiency and mitochondrial respiration in a porcine model of acute ischaemic heart failure?
Levosimendan failed to improve LV contractility or energy efficiency in a porcine model of acute ischemic heart failure, acting primarily as a vasodilator at high doses.
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Animal data question inotropic mechanism in acute ischemic HF; leaves open relevance to clinical levosimendan use.
Surprisingly, levosimendan had no significant effect on contractility, energy efficiency and mitochondrial respiration of the LV, in a porcine model of acute heart failure. At high doses, levosimendan induced vasodilatation and increased heart rate and cardiac output.
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Kolseth et al. (2011) studied this question.
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