What question did this study set out to answer?

To evaluate the maternal and developmental toxicity of perfluorobutyrate (PFBA) exposure during pregnancy in mice relative to other perfluoroalkyl acids.

May 28, 2008Toxicological Sciences

Effects of Perfluorobutyrate Exposure during Pregnancy in the Mouse

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Authors

KDKaberi DasUniversity of Calcutta BGBrian E. GreyThe University of Sydney RZRobert D. ZehrEnvironmental Protection Agency

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Implication

Animal study finds gestational perfluorobutyrate exposure causes modest developmental delays in mice, suggesting lower toxicity than long-chain perfluoroalkyl acids due to rapid elimination.

Key Points

To evaluate the maternal and developmental toxicity of perfluorobutyrate (PFBA) exposure during pregnancy in mice relative to other perfluoroalkyl acids.
Timed-pregnant CD-1 mice received PFBA/NH4(+) by oral gavage once daily from gestational day (GD) 1 to 17 at doses of 35, 175, or 350 mg/kg, with controls receiving water.
Maternal serum PFBA concentrations were measured on GD 18, reaching 3.8, 4.4, and 2.5 µg/mL across the 35, 175, and 350 mg/kg cohorts, respectively.
Outcomes assessed included maternal weight, full-litter loss, fetal morphology, neonatal survival, postnatal growth, hepatic gene expression, eye-opening timing, and puberty onset.
Maternal weight gain, implantation rates, fetal viability, fetal weight, and malformation rates were unaffected, but maternal liver weights rose at 175 and 350 mg/kg, and full-litter loss increased significantly at 350 mg/kg.
Neonatal survival and postnatal growth were unimpaired, and neonatal liver enlargement on postnatal day (PD) 1 resolved by PD 10 with no significant changes in selected hepatic gene expression.
Offspring exhibited significant delays in eye-opening across all treatment groups (35, 175, and 350 mg/kg) alongside slight delays in puberty onset in the 175 and 350 mg/kg groups.

Cite This Study

Das et al. (2008) studied this question.

synapsesocial.com/papers/69d9a0547f18ff2fefa3c0d6 https://doi.org/10.1093/toxsci/kfn099

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Implication

Animal study finds gestational perfluorobutyrate exposure causes modest developmental delays in mice, suggesting lower toxicity than long-chain perfluoroalkyl acids due to rapid elimination.

Effects of Perfluorobutyrate Exposure during Pregnancy in the Mouse

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of Perfluorobutyrate Exposure during Pregnancy in the Mouse

Discussion

Member takes

Implication

Key Points

Cite This Study

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