March 20, 2020CirculationOpen Access

Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension

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Population

PAH cases

Authors

Discussion

TET2 expression may inform PAH biomarker development; hypothesis-generating for targeted therapies.

Population

Patients with Pulmonary Arterial Hypertension (PAH)

Outcome

TET2 germline mutations and expression levelssurrogate

Decreased TET2 expression is ubiquitous in PAH and has potential as a biomarker, with TET2 mutations occurring in 0.39% of cases.

Potus et al. (2020) studied this question.

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