RVOT and LVOT arrhythmias share similar electrophysiologic mechanisms and should be classified together as a single entity of outflow tract arrhythmias.
Supports unified outflow tract arrhythmia classification; leaves open prospective validation of mechanism-targeted therapies.
Electrophysiologic and pharmacologic properties, including sensitivity to adenosine, are similar for RVOT and LVOT arrhythmias. Despite disparate sites of origin, these data suggest a common arrhythmogenic mechanism, consistent with cyclic AMP-mediated triggered activity. Based on these similarities, these arrhythmias should be considered as a single entity, and classified together as "outflow tract arrhythmias."
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Iwai et al. (2006) studied this question.
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