Why the study?
Enteroviruses counteract IFN-α/β transcription and stress granule formation, but the underlying mechanisms and the exact contribution of viral proteases 2Apro and 3Cpro remained poorly understood.
Does enterovirus 2A protease suppress stress granule formation and IFN-β gene transcription in infected cells?
Population
Cells infected with enterovirus species EV-A to EV-D or recombinant EMCV
Comparison
Enterovirus 2Apro vs 3Cpro
Design
Preclinical in vitro comparative study
Authors
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Suggests 2Apro as antiviral target in enterovirus infection; leaves open translation to human disease models.
Does enterovirus 2A protease suppress stress granule formation and IFN-β gene transcription in infected cells?
Enterovirus 2A protease plays a conserved and essential role in counteracting antiviral host responses by inhibiting stress granule formation and IFN-β gene transcription.
Visser et al. (2019) studied this question.
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