Key result
The Leader protein of cardioviruses actively inhibits the assembly of stress granules induced by viral infection or environmental stresses.
Population
HeLa, U3A 2FTGH, L929, and BHK-21 cell lines
Comparison
Infection with wild-type Theiler's murine… vs Infection with L-mutant TMEV viruses or mock…
Design
Preclinical
Follow-up
up to 24 hours post-infection
Authors
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No immediate clinical implications for cardiovirus infections; leaves open translation of stress granule inhibition to human disease.
The leader protein of cardioviruses actively inhibits host cell stress granule assembly, revealing a novel mechanism of viral antagonism.
Borghese et al. (2011) studied TMEV infection (in vitro). Wild-type TMEV (expressing L protein) vs. L-mutant TMEV or mock infection was evaluated on Stress granule (SG) assembly. The Leader protein of cardioviruses actively inhibits the assembly of stress granules induced by viral infection or environmental stresses.
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