Why the study?
Does DCA attenuate adverse metabolic remodeling in left ventricular hypertrophy or CHF?
Does DCA attenuate adverse metabolic remodeling in left ventricular hypertrophy or CHF?
DCA may attenuate adverse metabolic remodeling and reduce oxidative stress in the setting of left ventricular hypertrophy and heart failure.
Hypothesis-generating for DCA in HF metabolic remodeling; clinical translation requires prospective trials.
Left ventricular hypertrophy or CHF is associated with a distinct change in the metabolic profile of the heart. DCA attenuated the transition associated with increased energy reserves, activation of the pentose phosphate pathway, and reduced oxidative stress.
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Kato et al. (2010) studied this question.
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