Demonstrates that Ang-(1-7) from perivascular adipose tissue mediates vasorelaxation via endothelial nitric oxide release and K(Ca) channel activation.
Ang-(1-7) released by PVAT acts on the endothelium to cause the release of nitric oxide, and nitric oxide acts as a hyperpolarizing factor through K(Ca) channels to cause relaxation of the blood vessel.
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Lee et al. (2009) studied this question.
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