Demonstrates that Ang-(1-7) from perivascular adipose tissue mediates vasorelaxation via endothelial nitric oxide release and K(Ca) channel activation.
Ang-(1-7) released by PVAT acts on the endothelium to cause the release of nitric oxide, and nitric oxide acts as a hyperpolarizing factor through K(Ca) channels to cause relaxation of the blood vessel.
Lee et al. (Wed,) studied this question.