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August 10, 2004HypertensionOpen Access

Visceral Periadventitial Adipose Tissue Regulates Arterial Tone of Mesenteric Arteries

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Why the study?

Does periadventitial adipose tissue modulate contraction of mesenteric arteries?

Population

Mesenteric artery rings from adult male Sprague-Dawley rats

Comparison

Presence of periadventitial adipose tissue vs Vessels without periadventitial fat

Design

Preclinical

Authors

SVStefan VerlohrenGDGalyna DubrovskaSTSuk Ying Tsang

Discussion

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Overview

Periadventitial fat may attenuate mesenteric artery contraction via Kv channels; extends aortic data but leaves open human relevance.

Structured PICO

Does periadventitial adipose tissue modulate contraction of mesenteric arteries?

P
Population
Mesenteric artery rings from adult male Sprague-Dawley rats
I
Intervention
Presence of periadventitial adipose tissue (intact vessels)
C
Comparator
Vessels without periadventitial fat
O
Outcome
Contractile response to vasoactive substances (serotonin, phenylephrine, endothelin I, U46619, and depolarizing high K+-containing solutions)surrogate

Visceral periadventitial adipose tissue controls mesenteric arterial tone by inducing vasorelaxation via Kv channel activation in vascular smooth muscle cells.

Cite This Study

Verlohren et al. (2004) studied this question.

synapsesocial.com/papers/6a1d9455cc9f7df1b705a859https://doi.org/10.1161/01.hyp.0000140058.28994.ec
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