Key result
In rats, a cafe diet induces metabolic syndrome and impairs the anti-contractile protection of PVAT.
Why the study?
The modulatory effect of perivascular adipose tissue on vascular contractile activity during metabolic disorders induced by high-calorie diet remains poorly characterized.
Metabolic syndrome induced by a high-calorie diet impairs the protective, endothelium-independent anti-contractile effect of perivascular adipose tissue in rat aortas.
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No immediate clinical implications for metabolic syndrome; leaves open perivascular adipose tissue dysfunction as a vascular target in humans.
М. Н. Панькова (2023) studied Metabolic syndrome. Cafe diet vs. Standard diet was evaluated on Contractile activity of rat aortic smooth muscle and protective effect of PVAT. In rats, a 7-week cafe diet induced metabolic syndrome and decreased the endothelium-independent anti-contractile protective effect of perivascular adipose tissue on aortic smooth muscle.
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