Key result
Cafe diet-induced metabolic syndrome reduces the protective anticontractile effect of PVAT in rat aortas.
Why the study?
The modulatory effect of perivascular adipose tissue on vascular contractile activity during metabolic disorders induced by high-calorie diet remains poorly characterized.
Population
Rat thoracic aorta segments without endothelium
Comparison
Cafe diet-induced metabolic syndrome vs standard diet
Design
Preclinical study using wire myography on isolated aortic segments
Follow-up
7 weeks
Authors
Loading...
Impaired perivascular adipose tissue protection may promote vascular dysfunction in metabolic syndrome; hypothesis-generating and leaves open human translation.
Metabolic syndrome induced by a high-calorie diet impairs the protective, endothelium-independent anticontractile effect of perivascular adipose tissue in rat aortas.
М. Н. Панькова (2023) studied Metabolic syndrome. Cafe diet vs. Standard diet was evaluated on Vasoconstriction caused by phenylephrine and the protective effect of PVAT. In rats with metabolic syndrome induced by a cafe diet, the endothelium-independent anticontractile protective effect of perivascular adipose tissue on aortic smooth muscle was decreased.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: