Database update presents an expanded orthologous protein resource across prokaryotes and eukaryotes, facilitating genome annotation and broad evolutionary analyses.
The updated collection of orthologous protein sets for prokaryotes and eukaryotes is expected to be a useful platform for functional annotation of newly sequenced genomes, including those of complex eukaryotes, and genome-wide evolutionary studies.
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Tatusov et al. (2003) studied this question.
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