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This research demonstrates a photocatalytic method to synthesize 1,3-diamines using alkenes, suggesting new pathways for molecule production.
Herein, we report a photocatalytic carbonimination of alkenes for synthesizing 1,3-diamines, enabled by triplet-triplet energy transfer (TTEnT) catalysis and a formal 1,2-hydrogen atom transfer (1,2-HAT) of N-centered radicals. Through careful selection of the base and polar solvent to facilitate the 1,2-HAT step, selective carbonimination of alkenes is achieved, effectively suppressing the competing diamination pathway previously reported. This method demonstrates a broad substrate scope across a variety of oxime esters and alkenes, including examples of late-stage functionalization of bioactive molecules. Preliminary mechanistic studies support the involvement of a TTEnT process in the reaction.
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Wan et al. (2026) studied this question.
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