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April 11, 2026RSC Sustainability0 citationsOpen Access

Aerobic titania photocatalysis: selective oxidative dehydrogenation of tetrahydroisoquinoline and related amines

PRPaula Romero-NavarroIMIris Martín-GarcíaALAnabel E. Lanterna

Key Points

  • The aim is to explore aerobic photocatalysis for the selective oxidative dehydrogenation of tetrahydroisoquinoline and related amines.
  • Utilized titania (TiO2) as a photocatalyst under aerobic conditions.
  • Investigated reaction conditions for optimal dehydrogenation performance.
  • Employed synthetic methods to produce various tetrahydroisoquinoline derivatives.
  • Achieved selective oxidation of tetrahydroisoquinoline with high yields.
  • Demonstrated efficacy for a range of related amines.
  • Highlighted the potential of photocatalysis in drug synthesis applications.

Abstract

3,4-Dihydroisoquinolines are high-value chemicals, both as medicinally relevant compounds and as intermediates for the synthesis of 1,2,3,4-tetrahydroisoquinoline derivatives, which are widely regarded as privileged scaffolds in drug discovery. Though envisaged...

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Cite This Study

Romero-Navarro et al. (2026) studied this question.

synapsesocial.com/papers/69d9e64e78050d08c1b76ac4https://doi.org/10.1039/d6su00169f
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