What question did this study set out to answer?

The study aims to determine if isolated non-albumin proteinuria predicts kidney function decline in hypertensive patients with chronic kidney disease.

April 11, 2026Kidney & Blood Pressure ResearchOpen Access

Isolated non-albumin proteinuria was associated with the progression of chronic kidney disease in hypertensive patients: a retrospective cohort study

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Authors

GCGianluca ColussiUniversity of Ferrara NFNicholas FioriniUniversity of Udine SRS. RondinellaAzienda Ospedaliera Santa Maria Degli Angeli

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Implication

Retrospective cohort study reveals isolated non-albumin proteinuria predicts kidney decline in hypertensive chronic kidney disease patients, suggesting a need for monitoring.

Key Points

The study aims to determine if isolated non-albumin proteinuria predicts kidney function decline in hypertensive patients with chronic kidney disease.
Conducted a retrospective cohort analysis involving 166 hypertensive CKD outpatients with normal albuminuria.
Defined isolated non-albumin proteinuria as total 24-hour proteinuria ≥150 mg/day with albuminuria <30 mg/day.
Assessed kidney function change through eGFR trajectory and composite kidney endpoint using statistical models.
iNAP was present in 41 out of 166 participants; 32 reached the composite kidney endpoint and 25 died during follow-up.
eGFR decline was significantly faster in iNAP patients at −1.53 mL/min/1.73 m²/year compared to −0.61 mL/min/1.73 m²/year in normal proteinuria (p=0.011).
iNAP was linked to a higher risk of the composite kidney endpoint with a hazard ratio of 3.15 (p=0.001).

Cite This Study

Colussi et al. (2026) studied this question.

synapsesocial.com/papers/69d9e66378050d08c1b76cb2 https://doi.org/10.1159/000551406

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Implication

Retrospective cohort study reveals isolated non-albumin proteinuria predicts kidney decline in hypertensive chronic kidney disease patients, suggesting a need for monitoring.

Isolated non-albumin proteinuria was associated with the progression of chronic kidney disease in hypertensive patients: a retrospective cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

Isolated non-albumin proteinuria was associated with the progression of chronic kidney disease in hypertensive patients: a retrospective cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

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