Key result
A nonalbumin protein-to-creatinine ratio greater than 120 mg/g was associated with a significantly higher risk of CKD progression (HR 6.84) compared to a ratio below 120 mg/g in patients with type 2 diabetes.
Why the study?
Does the addition of nonalbumin proteinuria to albuminuria improve the prediction of CKD progression in patients with type 2 diabetes?
Population
325 outpatients with type 2 diabetes and an estimated glomerular filtration rate ≥ 30 mL/min/1.73 m2…
Comparison
Nonalbumin protein-to-creatinine ratio ≥ 120 mg/g vs Nonalbumin protein-to-creatinine ratio < 120 mg/g
Design
Cohort
Follow-up
median 4.3 years
Authors
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May support adding nonalbumin proteinuria to albuminuria for CKD risk assessment in type 2 diabetes; hypothesis-generating pending confirmatory studies.
Observational (n=325)
No
Does the addition of nonalbumin proteinuria to albuminuria improve the prediction of CKD progression in patients with type 2 diabetes?
Hazard Ratio: 6.84 (95% CI 2.25–20.85)
p-value: p=0.001
The addition of nonalbumin proteinuria to albuminuria improves the prediction of chronic kidney disease progression and accelerated eGFR decline in patients with type 2 diabetes.
Kim et al. (2017) conducted an observational in Type 2 diabetes (n=325). Nonalbumin protein-to-creatinine ratio (NAPCR) ≥120 mg/g vs. NAPCR <120 mg/g was evaluated on CKD progression (HR 6.84, 95% CI 2.25-20.85, p=0.001). A nonalbumin protein-to-creatinine ratio greater than 120 mg/g was associated with a significantly higher risk of CKD progression (HR 6.84) compared to a ratio below 120 mg/g in patients with type 2 diabetes.
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