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July 12, 1984New England Journal of Medicine

Of 14 patients with initial albumin excretion ≥15 µg/min, 12 developed clinically detectable proteinuria or excretion >150 µg/min, compared to 0 of 29 patients with initial excretion <15 µg/min.

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Why the study?

Does microalbuminuria predict the development of increased proteinuria in patients with Type I diabetes?

Population

44 patients who had had Type I diabetes for at least seven years and who had albumin excretion rates below…

Comparison

Presence of microalbuminuria at baseline. vs Albumin excretion rates below 15 micrograms per…

Design

Cohort

Follow-up

From 1969-1976 to 1983

Authors

CMCarl Erik MogensenCCCelanie K. Christensen

Discussion

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Overview

Microalbuminuria may predict proteinuria progression in type 1 diabetes; hypothesis-generating and requires confirmation in larger prospective studies.

Key Points

  • The study aims to determine if microalbuminuria can predict increased proteinuria in patients with Type I diabetes.
  • Forty-four Type I diabetes patients with albumin excretion rates below 150 micrograms per minute were studied over several years.
  • Initial examinations occurred in the 1960s and 1970s, with follow-up assessments in 1983.
  • Data on glomerular filtration rate, renal blood flow, and blood pressure were collected to assess their impact on proteinuria development.
  • Of the 14 patients with initial albumin excretion rates at or above 15 micrograms per minute, 12 developed clinically detectable proteinuria.
  • None of the 29 patients with initial rates below 15 micrograms per minute developed clinically detectable proteinuria.
  • Those progressing to proteinuria had elevated glomerular filtration rates and higher blood pressures at the initial examination.

Structured PICO

Does microalbuminuria predict the development of increased proteinuria in patients with Type I diabetes?

P
Population
44 patients who had had Type I diabetes for at least seven years and who had albumin excretion rates below 150 micrograms per minute.
I
Intervention
Presence of microalbuminuria (urinary albumin excretion rates of 15 to 150 micrograms per minute) at baseline.
C
Comparator
Albumin excretion rates below 15 micrograms per minute at baseline.
O
Outcome
Development of clinically detectable proteinuria (over 500 mg of protein per 24 hours) or an albumin excretion rate above 150 micrograms per minute at the later examination.surrogate

Cite This Study

Mogensen et al. (1984) studied this question.

synapsesocial.com/papers/6a1fda4a64bfae909d7e5940https://doi.org/10.1056/nejm198407123110204
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