What is the clinical evidence from this study?

Study design: Cohort. Population: Diabetes mellitus. Intervention: Rigorous control of glycemia. Primary outcome: Prevalence of microalbuminuria.

What does this research mean for the field?

Intermittent microalbuminuria occurs in approximately 20% of diabetic patients over a four-year period, and rigorous glycemic control leads to its cessation in nearly half of affected patients. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Determine the prevalence and clinical course of microalbuminuria over four years and assess its relationship with plasma prorenin levels and microvascular complications in diabetic patients.

April 1, 1988Archives of Internal Medicine

Microalbuminuria and increased plasma prorenin. Prevalence in diabetics followed up for four years

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Key result

Intermittent microalbuminuria occurred in 20% of diabetic patients over 4 years, and rigorous glycemic control led to its cessation in nearly half of affected patients.

Why the study?

Does rigorous glycemic control reduce microalbuminuria, and what is the association between microalbuminuria, plasma prorenin, and microvascular complications in diabetic patients?

Population

Patients with insulin-dependent diabetes mellitus (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM)

Design

Cohort

Follow-up

4 years

Authors

JLJohn A. LuetscherNovartis (Switzerland)

Discussion

Member takes

Implication

May support glycemic control to reverse microalbuminuria in diabetes; hypothesis-generating for prorenin and microvascular links.

Key Points

Determine the prevalence and clinical course of microalbuminuria over four years and assess its relationship with plasma prorenin levels and microvascular complications in diabetic patients.
Followed diabetic patients over a four-year period, measuring urinary albumin excretion with radioimmunoassay.
Defined microalbuminuria as urinary albumin excretion greater than 30 mg/g of urinary creatinine (more than twice the upper limit of normal).
Monitored rates of intermittent and continuous microalbuminuria, blood pressure, plasma prorenin levels, and response to rigorous glycemic control.
Intermittent microalbuminuria developed in 20% of patients with IDDM or NIDDM, while continuous microalbuminuria occurred in approximately 20% of NIDDM patients and less frequently in IDDM.
Rigorous glycemic control led to the cessation of microalbuminuria in nearly half of affected patients.
Microalbuminuria correlated with higher rates of microvascular complications and elevated plasma prorenin in IDDM, whereas hypertension (≥160/100 mm Hg) correlated with higher albumin excretion and lower prorenin levels.

Study Design

Type

Cohort

Structured PICO

Does rigorous glycemic control reduce microalbuminuria, and what is the association between microalbuminuria, plasma prorenin, and microvascular complications in diabetic patients?

Population

Patients with insulin-dependent diabetes mellitus (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM)

Intervention

Rigorous control of glycemia

Outcome

Prevalence of microalbuminuria and plasma prorenin valuessurrogate

Microalbuminuria is common in diabetic patients, is associated with higher plasma prorenin and microvascular complications, and may be reversible with rigorous glycemic control.

Cite This Study

John A. Luetscher (1988) conducted a cohort in Diabetes mellitus. Rigorous control of glycemia was evaluated on Prevalence of microalbuminuria. Intermittent microalbuminuria occurred in 20% of diabetic patients over 4 years, and rigorous glycemic control led to its cessation in nearly half of affected patients.

synapsesocial.com/papers/6a16a266798df06fa4b25ca0 https://doi.org/10.1001/archinte.148.4.937

Topics

Hypertension management

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Microalbuminuria and increased plasma prorenin. Prevalence in diabetics followed up for four years

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Microalbuminuria and increased plasma prorenin. Prevalence in diabetics followed up for four years

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider