October 1, 1986Journal of VirologyOpen Access

Genetic analysis of mRNA synthesis in adenovirus region E3 at different stages of productive infection by RNA-processing mutants

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Population

Adenovirus (wild-type rec700 and E3 deletion mutants)

Comparison

E3 deletion mutants (dl712, dl719) vs Wild-type virus (rec700)

Design

Preclinical

Authors

BBBheem M. BhatPfizer (United States)WWWilliam S.M. WoldSaint Louis University

Discussion

Member takes

Implication

Hypothesis-generating for adenoviral transcription; extends models of stage-specific promoter use but requires human validation.

Structured PICO

Population

Adenovirus (wild-type rec700 and E3 deletion mutants)

Intervention

E3 deletion mutants (dl712, dl719)

Comparator

Wild-type virus (rec700)

Outcome

Synthesis of E3 mRNAs at early and late stages of infectionsurrogate

This basic science study demonstrates that adenovirus E3 mRNA synthesis is differentially regulated at early and late stages of infection at both promoter and RNA-processing levels.

Cite This Study

Bhat et al. (1986) studied this question.

synapsesocial.com/papers/69d9f49a8988aeabbe6864a3 https://doi.org/10.1128/jvi.60.1.54-63.1986

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Genetic analysis of mRNA synthesis in adenovirus region E3 at different stages of productive infection by RNA-processing mutants

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Genetic analysis of mRNA synthesis in adenovirus region E3 at different stages of productive infection by RNA-processing mutants

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider