What question did this study set out to answer?

To introduce GalaxyWEB, an automated web server for predicting 3D protein structures from sequence and refining local structural regions.

May 30, 2012Nucleic Acids ResearchOpen Access

GalaxyWEB server for protein structure prediction and refinement

View Full Paper

Ask AI

Bookmark

Authors

JKJin Hwan KoJeju National University HPHahnbeom ParkUniversity of Washington LHLim HeoMichigan State University

Discussion

Member takes

Implication

Evaluation study demonstrates accurate template-based protein structure prediction and ab initio loop refinement, highlighting an accessible automated tool for structural biology.

Key Points

To introduce GalaxyWEB, an automated web server for predicting 3D protein structures from sequence and refining local structural regions.
Combines template-based modeling from multiple structural templates to assemble core scaffolds with ab initio modeling for terminus and loop regions.
Implements an optimization-based refinement protocol previously benchmarked under the identifier 'Seok-server' in the CASP9 community assessment.
Provides dual functionality allowing either full de novo structure prediction from sequence or targeted refinement of user-submitted coordinates.
Achieved top-performing server status for template-based modeling during independent CASP9 evaluations.
Successfully reconstructs unreliable or missing loop and terminus regions on top of reliable multi-template core structures.

Cite This Study

Ko et al. (2012) studied this question.

synapsesocial.com/papers/69da0c578988aeabbe686593 https://doi.org/10.1093/nar/gks493

View Full Paper

Ask AI

Bookmark

Implication

Evaluation study demonstrates accurate template-based protein structure prediction and ab initio loop refinement, highlighting an accessible automated tool for structural biology.

GalaxyWEB server for protein structure prediction and refinement

Discussion

Member takes

Implication

Key Points

Cite This Study

GalaxyWEB server for protein structure prediction and refinement

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider