Does iron deficiency defined by TSAT <20% better predict congestion, functional capacity, and prognosis in heart failure outpatients compared to ferritin-based definitions?
TSAT <20% is a superior marker for identifying clinically relevant iron deficiency associated with congestion, poor functional capacity, and worse prognosis in heart failure outpatients compared to traditional ferritin-based definitions.
In HF outpatients, TSAT <20% is more consistently associated with congestion by ultrasound and poorer functional capacity than other ID definitions, irrespective of LVEF. TSAT <20% and iron ≤13 μmol/L, but not G-ID or ferritin-based ID, predict a worse prognosis in HF outpatients with preserved and reduced LVEF.
Biase et al. (Thu,) studied this question.