How does epicardial adipose tissue accumulation affect cardiovascular haemodynamics, metabolic profile, and prognosis in heart failure?
Epicardial adipose tissue has a divergent prognostic impact in heart failure, with accumulation worsening outcomes in HFpEF but lower values predicting adverse prognosis in HFrEF.
In HFpEF, EAT accumulation is associated with worse haemodynamic and metabolic profile, also affecting survival. Conversely, lower EAT values imply higher left ventricular dysfunction, global functional impairment and adverse prognosis in HFrEF.
Pugliese et al. (Tue,) studied this question.