Cardiac extracellular vesicles released after acute myocardial infarction play a key mechanistic role in regulating local inflammatory responses via infiltrating monocytes.
The present study demonstrates that acute MI transiently increases the generation of cardiac EVs characterized as both exosomes and microvesicles, originating mainly from cardiomyocytes and endothelial cells. EVs accumulating in the ischemic myocardium are rapidly taken up by infiltrating monocytes and regulate local inflammatory responses.
Loyer et al. (Wed,) studied this question.