Why the study?
Does pharmacological inhibition of miR-21* attenuate cardiac hypertrophy in a mouse model of Ang II-induced cardiac hypertrophy?
Population
Mouse model of Ang II-induced cardiac hypertrophy and in vitro cardiac fibroblasts and cardiomyocytes
Design
Preclinical
Authors
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No immediate clinical implications; leaves open miR-21* inhibition as a target for human heart failure trials.
Does pharmacological inhibition of miR-21* attenuate cardiac hypertrophy in a mouse model of Ang II-induced cardiac hypertrophy?
Cardiac fibroblast-derived exosomes enriched with miR-21* mediate cardiomyocyte hypertrophy, and inhibiting miR-21* attenuates this pathology in vivo, highlighting a potential therapeutic target for heart failure.
Bang et al. (2014) studied this question.
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