Molecular Mechanisms Underlying the Transition of Cardiac Hypertrophy to Heart Failure
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Key result
The transition from cardiac hypertrophy to heart failure is mediated by complex molecular mechanisms including cardiac myocyte loss, abnormalities of calcium handling, and myocardial ischemia/hypoxia.
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Implication
Progress in hypertrophy mechanisms has enabled effective therapies; leaves open precise targets needed to lower persistent heart failure mortality.
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Heart failure and cardiac hypertrophy
Understanding the molecular mechanisms of cardiac myocyte loss, calcium handling abnormalities, and ischemia/hypoxia is crucial for developing novel therapies to prevent the transition from cardiac hypertrophy to heart failure.
Cite This Study
Oka et al. (2008) conducted a review in Heart failure and cardiac hypertrophy. The transition from cardiac hypertrophy to heart failure is mediated by complex molecular mechanisms including cardiac myocyte loss, abnormalities of calcium handling, and myocardial ischemia/hypoxia.
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