What question did this study set out to answer?

Review the phylogeny, ecophysiology, and diversity of Faecalibacterium prausnitzii and evaluate its utility as a clinical biomarker and therapeutic target in gut disorders.

January 3, 2017The ISME JournalOpen Access

Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics

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Authors

MLMireia López‐SilesUniversitat de Girona SDSylvia H. DuncanUniversity of Aberdeen LGL. J. Garcia‐GilUniversitat de Girona

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Implication

Narrative review highlights Faecalibacterium prausnitzii depletion across intestinal disorders, suggesting its utility as a diagnostic and prognostic biomarker for inflammatory bowel disease.

Key Points

Review the phylogeny, ecophysiology, and diversity of Faecalibacterium prausnitzii and evaluate its utility as a clinical biomarker and therapeutic target in gut disorders.
Synthesized literature on the phenotypic diversity, phylogenetic classification, and ecophysiology of Faecalibacterium prausnitzii.
Assessed distribution differences of bacterial phylogroups across healthy cohorts and individuals with intestinal diseases.
Examined therapeutic strategies to modulate bacterial abundance and analyzed its biomarker capacity to differentiate specific gut pathologies.
Identified at least two distinct F. prausnitzii phylogroups displaying divergent distribution patterns between healthy subjects and patients with intestinal disorders.
Observed a consistent reduction in F. prausnitzii abundance across multiple gastrointestinal pathologies.
Identified monitoring of F. prausnitzii as a viable biomarker candidate to aid in discriminating Crohn's disease from ulcerative colitis.

Cite This Study

López‐Siles et al. (2017) studied this question.

synapsesocial.com/papers/69da2873b48bb130d4684654 https://doi.org/10.1038/ismej.2016.176

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Implication

Narrative review highlights Faecalibacterium prausnitzii depletion across intestinal disorders, suggesting its utility as a diagnostic and prognostic biomarker for inflammatory bowel disease.

Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics

Discussion

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Implication

Key Points

Cite This Study

Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics

Discussion

Member takes

Implication

Key Points

Cite This Study

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