Answers are grounded in this paper and cite their sources.
3,4-Diaminopyridine has shown promise in reversing botulinum intoxication, but poor pharmacokinetics and a narrow therapeutic window limit its clinical utility. Thus, we developed a pH-dependent oral delivery platform using club moss spore exines. These exine microcapsules slowed 3,4-diaminopyridine absorption, limited its seizure activity, and enabled delivery of doses which prolonged mouse survival after botulism neurotoxin A intoxication.
No takes yet. Share an insight, caveat, or question.
Harris et al. (2016) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: