The burden of bacterial antimicrobial resistance in the WHO Eastern Mediterranean Region 1990–2021: a cross-country systematic analysis with forecasts to 2050

Tomislav Meštrović; Mohsen Naghavi; Gisela Robles Aguilar; Nicole Davis Weaver; Lucien R Swetschinski; Eve E Wool; Daniel T Araki; Anna Gershberg Hayoon; A B; Chieh Han; Kevin S Ikuta; Emily Rosenblad; Hasan Aalruz; Sherief Abd‐Elsalam; Armita Abedi; Hassan Abolhassani; Salahdein Aburuz; Saira Afzal; Aqeel Ahmad; Amir Mahmoud Ahmadzade; Ayman Ahmed; Haroon Ahmed; Abid Ali; Zahid Ali; Liaqat Ali; Syed Shujait Ali; Sabah Al-Marwani; Omar Almidani; Rami H. Al‐Rifai; Jaffar A. Al‐Tawfiq; Karem H. Alzoubi; Jessica Andretta Mendes; Jason R. Andrews; Jalal Arabloo; Mosab Arafat; Seyyed Shamsadin Athari; Maha Atout; Sina Azadnajafabad; Shahkaar Aziz; Khalil Azizian; Hiba Jawdat Barqawi; Zarrin Basharat; Neeraj Bedi; James A. Berkley; Natalia V. Bhattacharjee; Colin Brown; Yasser Bustanji; Ben S. Cooper; Nihar Ranjan Dash; Christiane Dolecek; Tim Eckmanns; Abdelaziz Ed‐Dra; Iman El Sayed; Muhammed Elhadi; Waseem El‐Huneidi; Christelle Elias; Sally Ellis; Ibrahim Elsohaby; Babak Eshrati; Ayesha Fahim; Ali Fatehizadeh; Shaffi Fazaludeen Koya; Alireza Feizkhah; Denise O Garrett; Ramy Mohamed Ghazy; Sama Ghoba; Konstantinos Giannakis; Rasool Haddadi; Mostafa Hadei; Sobia Ahsan Halim; Samer Hamidi; Ahmed I Hasaballah; Rumina Hasan; Hamidreza Hasani; Andrea Haselbeck; Bin Cao; Kamal Hezam; Mehdi Hosseinzadeh; Rebecca Hsu; Nawfal R Hussein; Mohammad Tarique Imam; Kenneth Iregbu; Faisal Ismail; Abdollah Jafarzadeh; Mahsa Jalili; Reza Jalilzadeh Yengejeh; Elham Jamshidi; Nabi Jomehzadeh; Zul Kamal; Hengameh Kasraei; Faham Khamesipour; Feriha Fatima Khidri; Suwimon Khusuwan; Mohammed Kuddus; Hmwe Hmwe Kyu; Mansour Adam Mahmoud; DF Omar Makram DE; Elaheh Malakan Rad; Florian Marks; Barney McManigal

doi:10.1016/s2468-2667(25)00201-4

October 11, 2025The Lancet Public HealthOpen Access

The burden of bacterial antimicrobial resistance in the WHO Eastern Mediterranean Region 1990–2021: a cross-country systematic analysis with forecasts to 2050

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Key Points

To assess the historical burden of bacterial antimicrobial resistance between 1990 and 2021 and project regional disease trends through 2050.
Synthesized cross-country data on bacterial antimicrobial resistance from 1990 to 2021 using systematic analytical frameworks.
Implemented statistical and epidemiological predictive models to estimate future regional resistance patterns and health outcomes up to 2050.
Historical assessments indicate substantial and persistent morbidity and mortality associated with drug-resistant bacterial pathogens across the region.
Predictive modeling indicates that bacterial antimicrobial resistance will escalate markedly through 2050 without targeted public health and stewardship interventions.

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Implication

Systematic analysis reveals the historical burden and future trajectory of bacterial antimicrobial resistance across regional populations, highlighting urgent global health intervention needs.

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Meštrović et al. (2025) studied this question.

synapsesocial.com/papers/69da547100ab073a2783834b https://doi.org/10.1016/s2468-2667(25)00201-4

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The burden of bacterial antimicrobial resistance in the WHO Eastern Mediterranean Region 1990–2021: a cross-country systematic analysis with forecasts to 2050

Key Points

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Implication

Abstract

Discussion

Cite This Study

The burden of bacterial antimicrobial resistance in the WHO Eastern Mediterranean Region 1990–2021: a cross-country systematic analysis with forecasts to 2050

Key Points

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Implication

Abstract

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Cite This Study

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