Why the study?
Does PI3K(p110alpha) play a critical role in the induction of physiological and pathological cardiac hypertrophy in transgenic mice?
Population
Transgenic mice expressing a dominant negative (dn) PI3K(p110alpha) mutant specifically in the heart
Design
Preclinical
Authors
Loading...
PI3Kα supports exercise hypertrophy and function under stress in mice; leaves open selective targeting for human cardiac remodeling.
Does PI3K(p110alpha) play a critical role in the induction of physiological and pathological cardiac hypertrophy in transgenic mice?
PI3K(p110alpha) is essential for physiological cardiac hypertrophy and for maintaining contractile function during pathological stress, but not for the induction of pathological hypertrophy.
McMullen et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: