Population
Hypopituitary adults with growth hormone deficiency prior to the onset of overt atherosclerotic disease
Design
Cross-sectional
Authors
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Should not change GH deficiency management; leaves open LDL as a potential modifiable contributor to endothelial dysfunction.
Endothelial dysfunction in GH-deficient adults correlates inversely with LDL-cholesterol, suggesting LDL may play an aetiological role in their excess cardiovascular risk.
Evans et al. (1999) studied this question.
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