What question did this study set out to answer?

To identify the functional ligand for the human orphan C-type lectin receptor CD161 (NKR-P1A) and determine its downstream signaling effects on immune cells.

December 1, 2005The Journal of Immunology

Cutting Edge: Lectin-Like Transcript 1 Is a Ligand for the CD161 Receptor

View Full Paper

Ask AI

Bookmark

Authors

HAHatice AldemirAdhera Therapeutics (United States)VPVirginie Prod’hommeInserm MDMarie-Jeanne DumaurierCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

In vitro experimental study demonstrates that LLT1 binding to CD161 modulates immune responses in human NK and T cells, highlighting distinct regulatory roles in innate and adaptive immunity.

Key Points

To identify the functional ligand for the human orphan C-type lectin receptor CD161 (NKR-P1A) and determine its downstream signaling effects on immune cells.
Evaluated the binding interaction between human CD161 and the lectin-like transcript 1 (LLT1) molecule.
Assessed natural killer cell-mediated cytotoxicity and interferon-gamma (IFN-gamma) secretion following LLT1-CD161 engagement on target cells.
Measured IFN-gamma production in T cells triggered by LLT1/CD161 interaction in the presence of T-cell receptor (TCR) stimulation.
LLT1 was identified as a specific functional ligand for the orphan human receptor CD161.
CD161 engagement by target-cell LLT1 inhibited NK cell-mediated cytotoxicity and suppressed IFN-gamma secretion.
LLT1-CD161 interaction co-stimulated T cells in the presence of a TCR signal, enhancing IFN-gamma production.

Cite This Study

Aldemir et al. (2005) studied this question.

synapsesocial.com/papers/69da65fc84371aa676a3d25b https://doi.org/10.4049/jimmunol.175.12.7791

View Full Paper

Ask AI

Bookmark

Implication

In vitro experimental study demonstrates that LLT1 binding to CD161 modulates immune responses in human NK and T cells, highlighting distinct regulatory roles in innate and adaptive immunity.

Cutting Edge: Lectin-Like Transcript 1 Is a Ligand for the CD161 Receptor

Discussion

Member takes

Implication

Key Points

Cite This Study

Cutting Edge: Lectin-Like Transcript 1 Is a Ligand for the CD161 Receptor

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider