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This review re-evaluates the biological roles of filaggrin in epidermal homeostasis and examines how filaggrin deficiency contributes to the pathogenesis of atopic dermatitis.

May 10, 2022International Journal of Molecular SciencesOpen Access

Revisiting the Roles of Filaggrin in Atopic Dermatitis

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Authors

VMVerena Moosbrugger‐MartinzInnsbruck Medical University CLCorinne LeprinceCentre National de la Recherche Scientifique MMMarie‐Claire MéchinCentre National de la Recherche Scientifique

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Implication

Narrative review uncovers distinct structural and barrier effects of filaggrin deficiency in atopic dermatitis, highlighting targets for designing efficacious therapies for dry and atopic skin.

Key Points

This review re-evaluates the biological roles of filaggrin in epidermal homeostasis and examines how filaggrin deficiency contributes to the pathogenesis of atopic dermatitis.
Synthesized experimental and clinical evidence evaluating filaggrin functions, upstream regulatory factors, and downstream effects of loss-of-function mutations in the filaggrin gene (FLG).
Analyzed literature on the impact of filaggrin deficiency on keratinocyte structure, epidermal barrier permeability, skin pH regulation, and transepidermal water loss.
Filaggrin maintains keratin intermediate filament alignment, keratinocyte shape, and hydration via water-retaining molecules, with deficiency permitting the entry of exogenous molecules.
While FLG null mutations reduce moisture in non-lesional atopic dermatitis skin, filaggrin deficiency alone does not drive skin surface pH neutralization or excessive transepidermal water loss.

Cite This Study

Moosbrugger‐Martinz et al. (2022) studied this question.

synapsesocial.com/papers/69da722a0f778bd2e4684da1 https://doi.org/10.3390/ijms23105318

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Implication

Narrative review uncovers distinct structural and barrier effects of filaggrin deficiency in atopic dermatitis, highlighting targets for designing efficacious therapies for dry and atopic skin.

Revisiting the Roles of Filaggrin in Atopic Dermatitis

Discussion

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Implication

Key Points

Cite This Study

Revisiting the Roles of Filaggrin in Atopic Dermatitis

Discussion

Member takes

Implication

Key Points

Cite This Study

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