What question did this study set out to answer?

To review the biochemical role of profilaggrin and filaggrin in epidermal differentiation and determine how loss-of-function FLG mutations disrupt barrier function to drive skin and allergic disorders.

April 22, 2009Journal of Cell ScienceOpen Access

Filaggrin in the frontline: role in skin barrier function and disease

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Authors

ASAileen SandilandsNinewells Hospital CSCalum SutherlandRoche (Switzerland)AIAlan D. IrvineTrinity College Dublin

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Implication

Genetic review demonstrates filaggrin loss impairs epidermal barrier integrity in human carriers, indicating cutaneous defects drive systemic allergic disease risk.

Key Points

To review the biochemical role of profilaggrin and filaggrin in epidermal differentiation and determine how loss-of-function FLG mutations disrupt barrier function to drive skin and allergic disorders.
Characterized the molecular processing cascade of profilaggrin dephosphorylation, endoproteolytic cleavage, citrullination, and degradation into natural moisturizing factor components.
Evaluated human genetic studies examining the prevalence and physiological impact of FLG loss-of-function mutations.
Loss-of-function FLG mutations, carried by up to 10% of the population, serve as the causative defect in ichthyosis vulgaris and act as major predisposing factors for atopic eczema, asthma, and allergies.
Monomeric filaggrin condenses the keratin cytoskeleton to facilitate squame biogenesis, while its citrullinated degradation products supply hygroscopic amino acids that form the natural moisturizing factor.
Deficiency or absence of filaggrin produces a defective stratum corneum with elevated transepidermal water loss and enhanced percutaneous allergen penetration, triggering abnormal immune responses.

Cite This Study

Sandilands et al. (2009) studied this question.

synapsesocial.com/papers/69de9d82210a0977fce94ec3 https://doi.org/10.1242/jcs.033969

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Implication

Genetic review demonstrates filaggrin loss impairs epidermal barrier integrity in human carriers, indicating cutaneous defects drive systemic allergic disease risk.

Filaggrin in the frontline: role in skin barrier function and disease

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Implication

Key Points

Cite This Study

Filaggrin in the frontline: role in skin barrier function and disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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