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March 5, 2015Clinical BiochemistryOpen Access

EDTA-mediated inhibition of DNases protects circulating cell-free DNA from ex vivo degradation in blood samples

Gustavo Barcelos Barra Ticiane Henriques Santa Rita Júlia de Almeida Vasques Camilla Figueiredo Chianca Lídia Freire Abdalla Nery Sandra Santana Soares Costa

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Abstract

The exogenous and endogenous DNases are more active in serum, the anticoagulant EDTA indirectly inhibits blood DNases, and consequently ccfDNA is protected from the blood's DNase preanalytical impact in EDTA-plasma.

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Cite This Study

Barra et al. (2015) studied this question.

synapsesocial.com/papers/69da7cbf114855a51268403b https://doi.org/10.1016/j.clinbiochem.2015.02.014

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