What question did this study set out to answer?

Characterize dynamic biological network perturbations across prion disease progression to identify core genetic drivers of neuropathology and incubation timing.

January 1, 2009SHILAP Revista de lepidopterologíaOpen Access

A systems approach to prion disease

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Authors

DHDaehee HwangSeoul National University ILInyoul Y. LeePohang University of Science and Technology HYHyuntae YooDaejeon University

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Implication

Systems biology study uncovers a core network of 333 differentially expressed genes in mouse models of prion disease, suggesting new mechanistic targets for therapy.

Key Points

Characterize dynamic biological network perturbations across prion disease progression to identify core genetic drivers of neuropathology and incubation timing.
Tracked temporal global gene expression in the brains of eight distinct mouse strain–prion strain combinations across disease incubation.
Performed subtractive analyses across host genetics, prion strains, and PrP concentrations to identify shared differentially expressed genes.
Mapped differential expression profiles into functional pathways and network modules linked to neuropathological changes and prion replication.
Identified a central core of 333 differentially expressed genes consistently perturbed during prion disease progression across all strains.
Mapped core genes into functional network modules that govern neuropathological damage, prion replication, host genetic susceptibility, and strain-specific incubation periods.

Cite This Study

Hwang et al. (2009) studied this question.

synapsesocial.com/papers/69da7f61387cf70698686cc5 https://doi.org/10.1038/msb.2009.10

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Implication

Systems biology study uncovers a core network of 333 differentially expressed genes in mouse models of prion disease, suggesting new mechanistic targets for therapy.

A systems approach to prion disease

Discussion

Member takes

Implication

Key Points

Cite This Study

A systems approach to prion disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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