What question did this study set out to answer?

To synthesize evidence on the cellular origins and spatiotemporal expression of TNF, IL-1, and IL-6 during the acute therapeutic window in experimental and human stroke.

June 27, 2012Journal of Cerebral Blood Flow & MetabolismOpen Access

Inflammatory Cytokines in Experimental and Human Stroke

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Authors

KLKate Lykke LambertsenUniversity of Southern Denmark KBKnut BiberAbbVie (Germany)BFBente FinsenUniversity of Southern Denmark

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Implication

Literature review demonstrates early microglial production of inflammatory cytokines within the ischemic penumbra, highlighting microglia as primary targets for acute stroke therapy.

Key Points

To synthesize evidence on the cellular origins and spatiotemporal expression of TNF, IL-1, and IL-6 during the acute therapeutic window in experimental and human stroke.
Reviewed experimental and clinical studies assessing the spatiotemporal dynamics of TNF, IL-1, and IL-6 within the ischemic penumbra during the early post-stroke window (<4.5 hours).
Analyzed reports examining cytokine profiles across peri-infarct brain tissue, systemic circulation, and cerebrospinal fluid.
TNF and IL-1 are upregulated rapidly in peri-infarct microglia within the early therapeutic window (<4.5 hours), whereas infiltrating macrophages arrive with a delay.
IL-6 is produced by both neurons and microglia in the ischemic territory, modulating neuronal susceptibility to ischemic injury.
Early localization of cytokine synthesis to peri-infarct microglia identifies these resident cells as pivotal cellular targets for neuroprotective interventions.

Cite This Study

Lambertsen et al. (2012) studied this question.

synapsesocial.com/papers/69da7f66cd426f8d32a3c1f4 https://doi.org/10.1038/jcbfm.2012.88

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Implication

Literature review demonstrates early microglial production of inflammatory cytokines within the ischemic penumbra, highlighting microglia as primary targets for acute stroke therapy.

Inflammatory Cytokines in Experimental and Human Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Inflammatory Cytokines in Experimental and Human Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

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