What question did this study set out to answer?

Synthesize evidence regarding the dual role of interleukin-6 as both a destructive inflammatory cytokine and a neuroprotective repair mediator following cerebral ischemia.

November 19, 2008Journal of Cerebral Blood Flow & MetabolismOpen Access

Ambivalent Aspects of Interleukin-6 in Cerebral Ischemia: Inflammatory versus Neurotrophic Aspects

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Authors

SSShigeaki SuzukiKeio University KTKortaro TanakaToyama College NSNorihiro SuzukiShowa University

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Implication

Review reveals dual inflammatory and neurotrophic actions of interleukin-6 in cerebral ischemia, indicating stage-dependent therapeutic targets.

Key Points

Synthesize evidence regarding the dual role of interleukin-6 as both a destructive inflammatory cytokine and a neuroprotective repair mediator following cerebral ischemia.
Evaluated cytokine expression patterns, cellular localization, and gp130-associated receptor distribution in peri-ischemic brain tissue.
Analyzed downstream intracellular signaling activation, specifically JAK-STAT and Stat3 pathways, during postischemic reperfusion and cytokine administration.
Interleukin-6 and leukemia inhibitory factor are prominently expressed in peri-ischemic neurons, targeting neuronal surface receptors that share the gp130 subunit.
Direct intracerebral injection of interleukin-6 reduces postischemic brain injury and activates neuronal Stat3 signaling during reperfusion.
Interleukin-6 operates bi-phasically, functioning primarily as an inflammatory mediator during acute ischemia and transitioning to a neurotrophic repair factor in subacute and prolonged phases.

Cite This Study

Suzuki et al. (2008) studied this question.

synapsesocial.com/papers/6a708bad5d37378ac1dda84e https://doi.org/10.1038/jcbfm.2008.141

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Implication

Review reveals dual inflammatory and neurotrophic actions of interleukin-6 in cerebral ischemia, indicating stage-dependent therapeutic targets.

Ambivalent Aspects of Interleukin-6 in Cerebral Ischemia: Inflammatory versus Neurotrophic Aspects

Discussion

Member takes

Implication

Key Points

Cite This Study

Ambivalent Aspects of Interleukin-6 in Cerebral Ischemia: Inflammatory versus Neurotrophic Aspects

Discussion

Member takes

Implication

Key Points

Cite This Study

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